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KMID : 1234520070020020190
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Korean Journal of Urogenital Tract Infection Inflammation
2007 Volume.2 No. 2 p.190 ~ p.196
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The Expression of CC Cytokine, Macrophage Inflammatory Protein in a Acute Cystitis and Bladder Pain Syndrome
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Kim Jun-Mo
Kim Chae-Hyun
Lee Yong-Wha
Lee Kwang-Woo
Kim Young-Ho
Kim Min-Eui
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Abstract
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Purpose: Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are members of the CC chemokine subfamily. To evaluate the changes of the expression of macrophage inflammatory protein-1 (MIP-1α and MIP-1β) by ELISA test in the patients with acute cystitis and bladder pain syndrome.
Materials and Methods: From January 2007 to May 2007, urine samples were obtained from 13 female control group, 16 female patients (mean age 44.8 years) with acute cystitis and 26 female patients (mean age 48.2 years) with bladder pain syndrome. The urine level of MIP-1α and MIP-1β were compared by enzyme linked immunosorbent assay (ELISA) test.
Results: The urine level of MIP-1α and MIP-1β was not significantly higher in both group than control group. But urine level of MIP-1α in patients with acute cystitis by E. coli was significantly higher than control group (p=0.006).
Conclusions: Although urine level of MIP-1α and MIP-1β in patients with acute cystitis and bladder pain syndrome were not higher than control group, MIP-1α was increased in acute cystitis by E. coli.
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KEYWORD
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Macrophage inflammatory protein-1, Cytokines, Cystitis, Interstitial
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